PROGRAMME & AGENDA

The First International Symposium on Computational Biology with AI

iscbAI 2025 Agenda

 

May 31st

8:25

Gathering at Prama Sanur Beach Hotel

8:25-8:45

Shuttle Bus to Tsinghua Southeast Asia Center

8:45-9:00

Sign-in and get badge

9:00-9:05

Opening Remarks - Xuegong Zhang

9:05-9:35

Keynotes
D-I-TASSER: Bridging Deep Learning and Physics-Based Simulation for Next-Generation Protein Folding

Speaker: Yang Zhang
Moderator: Xingming Zhao

 

 

 

9:35-10:45

Session 1 Interpretable AI models for biology and medicine

Moderator: Yong Wang/Zhen Xie

9:35-9:45  Tsung Fei KHANG

When Deep Learning Meets Traditional Taxonomy: Divergent Feature Interpretation in Fly Wing Venation Analysis

9:45-9:55  Hong Li

Interpretable AI Model to Identify Cellular and Spatial Biomarkers

9:55-10:05  Ruibang Luo

Optimizing long-term prevention of cardiovascular disease with reinforcement learning

10:05-10:15  Soichi Ogishima

Leveraging Large-scale Genome Cohorts: AI-Driven Prediction Model for Precision Prevention

10:15-10:25  Guoqiang Yu

Quantification and analysis of molecular spatiotemporal signals with advanced machine learning techniques

  10:25-10:35  Hebing Chen

  DNA Damage and Three-dimensional Genome

10:35-10:45  Anders Skanderup

AI-driven molecular diagnostics in onclogy

10:45-11:00

Break

 

 

 

11:00-12:00

Session 2  AI foundation models for DNA, RNA and proteins

Moderator: Xiaowo Wang/Zhihua Zhang

11:00-11:10   Tiannan Guo

Grow AI virtual cells with perturbation proteomics  

11:10-11:20   Jian Lu

AI-driven analysis of protein translation efficiency through RNA biology integration

11:20-11:30   Qiangfeng Zhang

Advancing Structural Biology: Harnessing AI Foundation Models for Precision Molecular Structure Determination

11:30-11:40 Stephen Bush

ANNEVO: A Mixture-of-Experts Genomic Language Model for Evidence-Free, Evolution-Aware Gene Annotation  

11:40-11:50  Louxin Zhang

HIG-Syn: A Hypergraph and Interaction-Aware Deep Learning Model for Precision Prediction of Synergistic Drug Combinations  

11:50 - 12:00  Yuanhua Huang

Assessing large-scale genomic language models in predicting personal gene expression: promises and limitations

12:00-13:00

Lunch

13:00-14:00

Group Discussion: Artificial intelligence vs. human intelligence:  Opportunities and concerns 

Moderator: Xiujie Wang

Discussants: Yixue Li, Shihua Zhang, Lu Xie, Zhang Zhang, Zhiwei Cao, Stephen Bush

14:00-14:20

Group Picture

14:20-16:20

Group Activity

16:20

Shuttle Bus to Prama Sanur Beach Hotel

18:00-20:00

Welcome Dinner at Beach

 

June 1st

8:30

Gathering at Prama Sanur Beach Hotel

8:30-9:00

Shuttle Bus to Tsinghua Southeast Asia Center

9:00-9:30

Keynotes: Towards a cell in silico
Speaker: Ge Gao
Moderator: Kai Ye

 

 

 

9:30-10:30

Session 3 AI for single-cell, spatial omics and multi-omics 

Moderator:Shihua Zhang/Hongmin Cai/Qi Liu

9:30-9:40   Boxiang Liu

Ancestry- and Sex-Biased Alternative Splicing in Immune Cells: Single-Cell Insights from the Asian Immune Diversity Atlas

9:40-9:50   Loza Martin

AI-Powered Spatial and Single-Cell Omics Analysis: STAIG and HyGAnno for Enhanced Domain Detection and Cell Type Annotation

9:50-10:00 Lin Hou

CausalPerturb: AI-Powered Causal Inference for Decoding Single-Cell CRISPR Perturbation Heterogeneity

10:00-10:10 Zhiwei Cao

Multi-omics-based AI discovery for lung cancer

10:10-10:20 Aziz Khan

Towards FAIR, diverse and reproducible multi-omics for AI-driven biology

10:20-10:30  Jiguang Wang

AI-Powered Multi-Omics Integration for Enhanced Cancer Subtyping

10:30-10:50

Break

 

 

 

10:50-12:00

Session 4

AI for microbiology, metagenomics & Industrial Applications

Moderator: Zhang Zhang/Yixue Li

  10:50-11:00   Didik H. Utomo

  Exploration of the Scientific Potential of Indonesian Herbal Medicine

11:00-11:10   Weihua Chen

Best Practices for Developing Microbiome-Based Disease Diagnostic Classifiers through Machine Learning

11:10-11:20   Shuhua Xu

AI for Human Evolution

11:20-11:30  Limsoon Wong

SORCERER: Second-Order Relational Contrastive Learning for Robust Knowledge Graph Reasoning

11:30-11:40  Joshua Ho

AI vs. Cardiologists in Murmur Detection: A Prospective Clinical Benchmark Using Smartphones and Digital Stethoscopes

11:40-11:50  Gang Chen

From Million Personal Genomes to Personal Omics Intelligence

12:00-13:00

Lunch

13:00-14:00

Group Discussion:Are we assessing the performance of AI on computational biology problems properly? Time for some guidelines?

ModeratorLimsoon Wong

Discussants: Joshua Ho, Jiangning Song, Tsung Fei Khang, Lin Hou

14:00-17:30

Cultural Activity

17:30

Shuttle Bus to Prama Sanur Beach Hotel

 

June 2nd

8:30

Gathering at Prama Sanur Beach Hotel

8:30-8:50

Shuttle Bus to Tsinghua Southeast Asia Center

 

 

 

9:00-10:00

Session 5 AI-Enabled Precision Medicine & Biomarker Discovery

Moderator:Hairong Lv/Weiwei Zhai

9:00-9:10  Jiangning Song

Accelerating Biomedical Discovery Through Machine Learning: A Unified Framework for Multi-Dimensional Molecular Data Analysis   

9:10-9:20  Guoliang Li

Title: Identification of pan-cancer differentially methylated regions enables non-invasive diagnosis of seven cancer types.

9:20-9:30  Anders Skanderup

VarNet: An AI-Driven Deep Learni3g Model for Accurate Somatic Variant Detection in Cancer Genomics  

9:30-9:40  Youqiong Ye

Cellular Senescence Detection via Single-cell Foundation Model Identifies Spatially-resolved Senescent Programs Driving Tumor Immune Evasion

9:40-9:50  Toshiaki Katayama

Technological Developments for Integrating Life Science Knowledge Graphs

10:00-10:20

Break

10:20-11:20

Panel DiscussionInternational Academic Exchanges and Collaborations in AI Computational Biology in the New Era

ModeratorXuegong Zhang

Joshua Ho, Aziz Khan, KHANG Tsung Fei, Toshiaki Katayama, Xingming Zhao, Kai Ye

11:20-11:30

Closing Remarks - Xiujie Wang

Moderator:Xuegong Zhang

11:30-12:30

Lunch

12:30

Shuttle Bus to Prama Sanur Beach Hotel

 

 

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